About Our Research Group
Our group is based at Griffith Institute for Drug Discovery (GRIDD) and Discovery Biology at Griffith University (Brisbane, Australia). We are working on developing innovative approaches to better understand human diseases and find bioactive compounds with therapeutic potential. Our ultimate goal is to define and develop the therapeutics of tomorrow
Quick video presenting the interest of the zebrafish animal model for both medical research and drug discovery. Please give credit to the Giacomotto’s LAB if you use this video or some part of it. ©Giacomotto’s LAB
Here, a quick video illustration of the zebrafish neuromuscular system. Thanks to its transparency, this animal is a brilliant model to study human diseases and affected cells or tissues. ©Giacomotto’s LAB
We have developed zebrafish models presenting progressive loss of motor function secondary to motor neuron degeneration. We are using those unique research models to study the underlying mechanisms responsible for abnormal cell death.
The zebrafish is a fantastic animal to study early development and diseases. It is transparent and develops quickly with organs similar to human. One can easily track cells or tissues involved in specific diseases to better understand the underlying pathogenic mechanisms.
Quick animation presenting the whole nervous system, striated muscle fibres, and mitochondria in an alive zebrafish.
Quick video presentation of our projects focusing on motor neuron diseases (MNDs).
Now hosted at Griffith Research Institute for Drug Discovery (GRIDD) and Discovery Biology (Griffith University).
A 10 minute talk presenting the power of phenotypic screening and chemical genetics (extract from a 2017 seminar).